MOTS-C

MOTS-C

MOTS-C (Mitochondrial ORF of the 12S rRNA type-C) is a mitochondrial-derived peptide that regulates cellular energy metabolism. It enhances glucose utilization and fatty acid oxidation by activating AMPK and promoting metabolic flexibility. MOTS-C also counteracts insulin resistance and protects against diet-induced obesity. Emerging research suggests it plays a crucial role in exercise adaptation, cellular stress resistance, and longevity by improving mitochondrial biogenesis and reducing metabolic inflammation.